The park was created in 1937 as a way to preserve a representative area of the Sonoran Desert. The new monument was part of a movement in the National Parks to protect not just scenic wonders but also the ecological wonders of the country. Over 75 years later, Organ Pipe Cactus is now one of the best preserved examples of the Sonoran Desert wilderness.
Within the monument, signs of human use are also preserved and protected. The monument is the site of culture and history that reflect long, widespread and diverse use by American Indian, Mexican, and European groups. The intesection of these of these three cultures is significant archeologically, geographically, and internationally.